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Dr. Boye is pleased to be working with a fantastic team at Genzyme/Sanofi to develop a treatment for a form of childhood blindness
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Our Research Focus

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The focus of our research is developing viral vector-based gene replacement strategies for the treatment of inherited ocular disease. Our current goals are:

  • to develop AAV-based gene therapy approaches for delivering genes to the outer retina (notably foveal cones) following intravitreal delivery
  • to develop an AAV-based gene therapy for treatment of GUCY2D-Leber congenital amaurosis-1 (LCA1)
  • to develop dual AAV vector platforms that are capable of delivering large transgenes (> 5kb)
  • to develop gene replacement therapies for various forms of Congenital Stationary Night Blindness (CSNB), a disorder caused by mutations in genes which express bipolar cell- specific proteins.

Recent News

Taking the fight across the pond

I was so fortunate to be asked to speak at the Fighting Blindness Retina 2015 International Conference, supported by Novartis, which took place in Croke Park, Dublin, Ireland! Sight loss affects ~224,000 […]

New study from the Boye lab featured on the cover of Human Gene Therapy

Congratulations to Tyler for taking the photo which got the cover of last issue’s Human Gene Therapy. And thank you to the entire Boye lab for contributing to this featured […]

Tyler McCullough and “Mack” take time to make a difference in the lives of patients at UF Health

When he’s not busy conducting gene therapy experiments at the bench, our very own K. Tyler McCullough graciously volunteers his time at UF Health where he brightens the day of many a patient […]

Congratulations to Miranda White (soon to be Miranda Scalabrino) on her first, first author publication!

Miranda’s work on developing a gene therapy for Congenital Stationary Night Blindness was just accepted in Human Molecular Genetics. Click here to see the fruits of her labor! http://www.ncbi.nlm.nih.gov/pubmed/26310623

Upcoming Events

MIRANDA’S WEDDING!

The very first graduate student of the Boye lab will officially become Miranda Scalabrino this December 19th! Congratulations Miranda and Anthony!

Center for Vision Research Annual Symposium 11-2-15

“From Bench to Branding: Bringing Research Discoveries to Life”- McKnight Brain Institute, DeWeese Auditorium, 8:00-5:00

Summer 2015- The Big Move

In case you’re looking for the Boye lab, we are currently housed in M-119 of the Medical Sciences Building. We brought our capsids with us!

Boye lab research being presented at ARVO 2015

Please stop by the following talks or posters being presented by members of the Boye lab: “AAV-mediated rescue of a mouse model of X-linked Congenital Stationary Night Blindness” Miranda White […]

Creed’s Cause 5K- May 2nd, 2015

Please come out to support LCA research by registering for Creed’s Cause 5K at the following link: https://4thannualcreedscause5k.itsyourrace.com/register/default.aspx