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Dr. Boye is pleased to be working with a fantastic team at Genzyme/Sanofi to develop a treatment for a form of childhood blindness
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Our Research Focus

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The focus of our research is developing viral vector-based gene replacement strategies for the treatment of inherited ocular disease. Our current goals are:

  • to develop AAV-based gene therapy approaches for delivering genes to the outer retina (notably foveal cones) following intravitreal delivery
  • to develop an AAV-based gene therapy for treatment of GUCY2D-Leber congenital amaurosis-1 (LCA1)
  • to develop dual AAV vector platforms that are capable of delivering large transgenes (> 5kb)
  • to develop gene replacement therapies for various forms of Congenital Stationary Night Blindness (CSNB), a disorder caused by mutations in genes which express bipolar cell- specific proteins.

Recent News

Tyler McCullough and “Mack” take time to make a difference in the lives of patients at UF Health

When he’s not busy conducting gene therapy experiments at the bench, our very own K. Tyler McCullough graciously volunteers his time at UF Health where he brightens the day of many a patient […]

Congratulations to Miranda White (soon to be Miranda Scalabrino) on her first, first author publication!

Miranda’s work on developing a gene therapy for Congenital Stationary Night Blindness was just accepted in Human Molecular Genetics. Click here to see the fruits of her labor! http://www.ncbi.nlm.nih.gov/pubmed/26310623

Shannon and Sanford Boye receive 2014 Technology Innovator Awards

Dr. Shannon Boye and Sanford Boye were honored this year at the University of Florida’s Celebration of Innovation for successfully transferring their world-class research to a commercial partner. The University […]

ARVO 2015 Highlights

The Boye lab had many firsts at this year’s ARVO conference in Denver. Miranda White gave her first platform presentation. Sadly it was concurrent with mine and I missed it, […]

Upcoming Events

Summer 2015- The Big Move

In case you’re looking for the Boye lab, we are currently housed in M-119 of the Medical Sciences Building. We brought our capsids with us!

Boye lab research being presented at ARVO 2015

Please stop by the following talks or posters being presented by members of the Boye lab: “AAV-mediated rescue of a mouse model of X-linked Congenital Stationary Night Blindness” Miranda White […]

Creed’s Cause 5K- May 2nd, 2015

Please come out to support LCA research by registering for Creed’s Cause 5K at the following link: https://4thannualcreedscause5k.itsyourrace.com/register/default.aspx

Celebration of Research

On February 9th, 2015, the Boye lab will be presenting 3 major research projects at the UF College of Medicine’s Celebration of Research. Join us in the O’Connell center to […]

Center for Vision Research Seminar 11/19/14

“High Resolution Transcriptomics: Dissecting the Molecular Program Underlying Retinal Development”- Rahul Kanadia