The Boye Lab

Boye lab research was featured in a recent FFB video.

Visitors like little Robert motivate us to develop cures for blindness

We were so happy to host Janice, Hugh, and Robert in our lab this month. They came all the way from Australia to learn more about our work on GUCY2D-LCA1. […]

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Our Research Focus

HGT art
The focus of our research is developing viral vector-based gene replacement strategies for the treatment of inherited ocular disease. Our current goals are:

  • to develop AAV-based gene therapy approaches for delivering genes to the outer retina (notably foveal cones) following intravitreal delivery
  • to develop an AAV-based gene therapy for treatment of GUCY2D-Leber congenital amaurosis-1 (LCA1)
  • to develop dual AAV vector platforms that are capable of delivering large transgenes (> 5kb)
  • to develop AAV-CRISPR/Cas9- based treatments for inherited retinal disease
  • to develop AAV vectors capable of targeting retinal bipolar cells to correct Congenital Stationary Night Blindness (CSNB) and restore vision via optogenetics.

Recent News

Congratulations Dr. McCullough!

K. Tyler McCullough successfully defended his Ph.D. thesis on March 25th, 2019! We are excited that Tyler decided to join grad school (aka come to the ‘dark side’), and to […]

The Boye Lab presents their work in 4 talks at ASGCT 2019!

Congratulations to Sean Crosson, Ph.D., Kaitlyn Calabro, and Russell Mellen for giving outstanding presentations at this year’s ASGCT meeting in Washington D.C.! Along with Dr. Boye, they rounded out 4 […]

The most heartwarming surprise from across the pond

As if loving what you do for a living wasn’t enough, today I received a beautiful bouquet of flowers from a grateful patient all the way in Denmark. Thank you […]

The first report of AAV-CRISPR/Cas9 mediated somatic gene editing in primate published by the Boye Lab

Genome-editing technologies that correct specific mutations represent a transformative new approach for treating genetic disorders. Despite its widespread use in mouse models of disease, and in cell lines, the Boye […]

Congratulations to my mentor for her Innovator of the Year Award!

“When you get where you’re goin’, don’t forget turn back around. Help the next one in line. Always stay humble and kind”. These lyrics from Tim McGraw (yes, I like […]

Upcoming Events

Kaitlyn Calabro presents her work to develop a gene therapy for MyosinVIIa Usher syndrome in Kilarney Ireland

Doctoral candidate Kaitlyn Calabro had the pleasure of presenting her work this week at the Retinal Degeneration meeting in Ireland. She summarized her efforts to characterize a novel mouse model […]

Boye Lab Research will be featured in 10 talks/posters at international meetings this month!

We welcome everyone to come hear our talks/visit our posters at this year’s Retinal Cell and Gene Therapy Innovation Summit, ARVO and ASGCT meetings. Below is a list of all […]

January 23rd, 2017- Ciliated Senses: Biology, Pathology, and Treatment” — Center for Vision Research symposium

Boye lab research (owed mostly to graduate student Kaitlyn Calabro) to develop a dual AAV vector-mediated strategy to treat MYO7A Usher syndrome (USH1B) will be featured in this symposium.

Dr. Scalabrino’s Commencement Ceremony

We are excited to celebrate our newest doctor at the Annual College of Medicine Graduate Convocation on Thursday, April 28, 11:00-12:00. Miranda and I will be tirelessly practicing the hooding […]

ARVO- Seattle

Looking forward to presenting Boye Lab research May 1st-5th in Seattle! Sunday, May 1st, 1:30-3:15: Shreyasi Choudhury’s poster, “Novel Methodology for Creating Primate Retina with Sortable Cell Populations: Monday, May 2nd, […]